If you ever feel lonely, think about the billions of bacteria populating your warm and comfortable gut: the dream house! More than 500 different species of microorganisms hanging around in our gut are a lot and do not go unnoticed: they modulate inflammatory processes and homeostasis in all host organs through metabolic and immune regulatory functions…and all this, while they are “trapped” in the gut! Their metabolites can in fact reach distant organs…and the host antibodies can control their absorption and distribution!