Every cancer is different, so why should therapy be one? Personalized medicine is the new frontier in immunotherapy and aims at targeting tumour specific mutations, which differ between patients. Researchers from the University of Pennsylvania developed a personalized vaccine against ovarian cancer, which is safe and induces a broad antitumor immunity. Further clinical investigations are required to assess the efficacy of such vaccine: in the meantime, aren’t you curious to find out which strategy they used?