In 2012, Chelonoidis abingdonii a species of giant tortoises and a symbol of the Galapagos Islands became extinct. Its last individual, Lonesome George, died at the age of 100. From our perspective, a century is a lot. Yet George was actually in his prime: its species could live up to 200 years old! Which are the secrets of such an extraordinary longevity? The analysis of the genetic sequences of Lonesome George and another species of giant tortoises (Aldabrachelys gigantea) has shed some light on the characteristics of these animals, including their resistance to cancer and ageing.